MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexiophenone)
MDPHP belongs to the synthetic cathinone family. Researchers and users often call it a “designer stimulant.” It shares structural similarities with MDPV, α-PVP, and other pyrovalerones. The full chemical name is 3′,4′-methylenedioxy-α-pyrrolidinohexiophenone. People first reported MDPHP around 2014–2015 on online research chemical forums. Since then, it has appeared sporadically in Europe, the United States, and parts of Asia. In 2026, interest remains low compared to more common cathinones or classic stimulants. Still, MDPHP circulates in niche markets and draws attention from harm-reduction communities.
Chemical Structure and Effects
MDPHP features a pyrrolidine ring attached to a hexanophenone backbone with a 3,4-methylenedioxy substitution on the phenyl ring. This methylenedioxy group links it to MDMA-like compounds. The pyrrolidine ring and extended alkyl chain give it strong stimulant properties similar to MDPV and α-PHP. Users describe MDPHP as producing intense euphoria, increased energy, alertness, talkativeness, and enhanced sensory perception. Many report a strong compulsive redosing urge. The rush feels sharp and short-lived. Duration usually lasts 2–4 hours after oral or nasal use. Higher doses often lead to agitation, paranoia, vasoconstriction, rapid heart rate, elevated blood pressure, and insomnia. Some users experience severe anxiety, panic, or psychosis-like states during or after the peak.
Comparison to Related Compounds
MDPHP acts more like MDPV than MDMA. It delivers powerful dopamine and norepinephrine release with much less serotonin activity. This profile creates a “wired” stimulant high rather than the warm empathogenic feeling of MDMA. Compared to α-PVP or α-PHP, MDPHP feels slightly smoother to some users. Others find it harsher on the body with stronger peripheral stimulation and vasoconstriction. The methylenedioxy ring adds mild entactogenic notes at low doses. At higher doses, however, the stimulant side dominates completely.
Reported Risks and Health Concerns
Users frequently mention rapid tolerance. Compulsive redosing often occurs within the first hour. This pattern increases the chance of overdose symptoms. Acute risks include severe hypertension, tachycardia, hyperthermia, dehydration, rhabdomyolysis, and seizures. Long-term or heavy use links to cardiovascular strain, kidney damage, cognitive impairment, persistent anxiety, depression, and cravings. Several case reports describe MDPHP-related psychosis, agitation, and emergency department visits. The compound also shows up in post-mortem toxicology in some stimulant-related fatalities, usually alongside other drugs. Harm-reduction groups stress the importance of reagent testing, small test doses, and avoiding mixing with other stimulants, alcohol, or serotonergic substances.
Legal Status in 2026
MDPHP remains unscheduled at the international level under the UN conventions. Most countries, however, control it through analog acts or specific bans. In the United States, it falls under the Federal Analogue Act when intended for human consumption. Many European countries (United Kingdom, Germany, France, Netherlands, Switzerland, Finland, Austria) list MDPHP as a controlled substance or narcotic. Sweden and Belgium apply similar strict controls. Japan and China enforce near-total bans on cathinones. Australia classifies MDPHP as a Schedule 9 prohibited substance. New Zealand and Canada treat it as a controlled analog. Dubai and the UAE impose severe penalties for any synthetic cathinone possession or use. Always check current national legislation before any research or handling.
Current Availability and Market Trends
MDPHP appears sporadically on darknet markets, clearnet research chemical vendors, and private networks. Availability fluctuates more than with popular cathinones. Many vendors label it “not for human consumption” to avoid legal scrutiny. Purity varies widely. Adulteration with other cathinones, caffeine, or fentanyl occurs in street samples. Harm-reduction communities strongly recommend reagent testing (Marquis, Mecke, Froehde) and, when possible, lab analysis. In 2026, interest remains niche. Most stimulant users prefer methamphetamine, cocaine, or more established cathinones.
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MDPHP remains a potent synthetic cathinone with strong stimulant effects and significant risks. Its niche status keeps it out of the mainstream. Still, harm-reduction communities monitor its appearance closely. Anyone researching or encountering MDPHP should prioritize safety, testing, and accurate information.
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