Researchers are investigating psilocybin as a potential treatment for many health disorders. These include:

Substance Use Disorders 

Preliminary research indicates that psilocybin may be helpful in treating substance use disorders, including tobacco use disorder. NIDA is funding a large, multi-site study on the effectiveness of psilocybin versus a nicotine patch, in combination with therapy, to help people stop smoking.

Depression and Anxiety 

There is evidence that psilocybin may be an effective treatment for depression and anxiety disorders. To support further research, the FDA granted “Breakthrough Therapy” designation for two formulations of psilocybin being studied for safety and efficacy as a medical treatment for depression.

Research suggests that some psychedelics can reduce anxiety and depression in people with cancer, and can promote well-being, quality of life, and acceptance of their illness and related issues. The National Cancer Institute, part of the National Institutes of Health, is funding a follow-up multi-site clinical trial to investigate the use of psilocybin to treat cancer-related mental health issues.

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